Cepheid1

Red opsin-FRET voltage indicator pair featuring RFP donor insertion into the first extracellular loop of Ace rhodopsin for large voltage-dependent response with improved brightness or photostability.

Category: eFRET GEVI · Published: 2023 · Science Advances 2023

Speed: τ_on=1.88 ms, τ_off=2.89 ms

Dynamic Range: -32.9% ΔF/F per 100mV

Sensitivity: 12.1% ΔF/F per AP

Brightness: 1.65× vs varnam

Research Papers (2)

Bright and sensitive red voltage indicators for imaging action potentials in brain slices and pancreatic islets — Han Y, Yang J, Li Y, Chen Y, Ren H, Ding R, Qian W, Ren K, Xie B, Deng M, Xiao Y, Chu J, Zou P, Science Advances 2023
Positive-going hybrid indicators for voltage imaging in excitable cells and tissues — Liu S, Ling J, Xie B, Zhang Y, Peng L, Yang L, Yu Y, Lin J, Tang C, Chen Z, Zou P, Science Advances 2025