MacQ

Early opsin-fluorescent protein FRET voltage indicator, fusing the Mac rhodopsin to mCitrine.

Category: eFRET GEVI · Published: 2014 · Nature Communications 2014

Speed: τ_on=2.8 ms, τ_off=5.4 ms

Dynamic Range: -20% ΔF/F per 100mV

Sensitivity: 4.8% ΔF/F per AP

Brightness: 3× vs arclight

Research Papers (5)

Imaging neural spiking in brain tissue using FRET-opsin protein voltage sensors — Gong Y, Wagner MJ, Zhong Li J, Schnitzer MJ, Nature Communications 2014
High-speed recording of neural spikes in awake mice and flies with a fluorescent voltage sensor — Gong Y, et al., Science 2015
Cell-Type-Specific Optical Recording of Membrane Voltage Dynamics in Freely Moving Mice — Marshall JD, Li JZ, Zhang Y, Gong Y, St-Pierre F, Lin MZ, Schnitzer MJ, Cell 2016
Fast two-photon imaging of subcellular voltage dynamics in neuronal tissue with genetically encoded indicators — Chamberland S, et al., eLife 2017
Rhodopsin-based voltage imaging tools for use in muscles and neurons of Caenorhabditis elegans — Azimi Hashemi N, et al., PNAS 2019