HVI

Chemigenetic GEVI that conjugates dyes to an Ace2 rhodopsin.

Category: Chemigenetic GEVI · Published: 2021 · Nature Chemistry 2021

Speed: τ_on=1.7 ms, τ_off=2.5 ms

Dynamic Range: -39% ΔF/F per 100mV

Sensitivity: 25.3% ΔF/F per AP

Brightness: 0.19× vs voltron

Research Papers (3)

A far-red hybrid voltage indicator enabled by bioorthogonal engineering of rhodopsin on live neurons — Liu S, Lin C, Xu Y, et al., Nature Chemistry 2021
Orange/far-red hybrid voltage indicators with reduced phototoxicity enable reliable long-term imaging in neurons and cardiomyocytes — Liu S, Ling J, Chen P, et al., Proceedings of the National Academy of Sciences 2023
Positive-going hybrid indicators for voltage imaging in excitable cells and tissues — Liu S, Ling J, Xie B, et al., Science Advances 2025