LOTUS-V

First bioluminescent FRET-based voltage indicator, enabling excitation-free ratiometric imaging.

Category: Bioluminescent GEVI · Published: 2017 · Scientific Reports 2017

Speed: τ_on=3.09 ms, τ_off=6.12 ms

Dynamic Range: 21% ΔF/F per 100mV

Sensitivity: 2.8% ΔF/F per AP

Brightness: 0.586× vs arclight

Research Papers (2)

Genetically encoded bioluminescent voltage indicator for multi-purpose use in wide range of bioimaging — Inagaki S, Tsutsui H, Suzuki K, Agetsuma M, Arai Y, Jinno Y, Bai G, Daniels MJ, Okamura Y, Matsuda T, Nagai T, Scientific Reports 2017
Imaging local brain activity of multiple freely moving mice sharing the same environment — Inagaki S, Agetsuma M, Ohara S, Iijima T, Yokota H, Wazawa T, Arai Y, Nagai T, Scientific Reports 2019