Voltron
Breakthrough chemigenetic GEVI that binds fluorescent dyes with exceptional brightness and photostability.
Category: Chemigenetic GEVI · Published: 2019 · Science 2019
Speed: τ_on=0.85 ms, τ_off=1.13 ms
Dynamic Range: -23% ΔF/F per 100mV
Sensitivity: 6.16% ΔF/F per AP
Brightness: 4× vs ace2n-mneon
Research Papers (9)
- Bright and photostable chemigenetic indicators for extended in vivo voltage imaging — Abdelfattah AS, Kawashima T, Singh A, et al., Science 2019
- High-fidelity estimates of spikes and subthreshold waveforms from 1-photon voltage imaging in vivo — Xie ME, et al., Cell Reports 2021
- VolPy: Automated and scalable analysis pipelines for voltage imaging datasets — Cai C, et al., PLOS Computational Biology 2021
- Single Photon Kilohertz Frame Rate Imaging of Neural Activity — Tian T, Yuan Y, Mitra S, et al., Advanced Science 2022
- Voltage-Seq: all-optical postsynaptic connectome-guided single-cell transcriptomics — Csillag V, et al., Nature Methods 2023
- All-optical voltage imaging-guided postsynaptic single-cell transcriptome profiling with Voltage-Seq — Csillag V, Noble JC, Calvigioni D, et al., Nature Protocols 2024
- Dynamic assemblies of parvalbumin interneurons in brain oscillations — Huang YC, et al., Neuron 2024
- Optical Recordings of Unitary Synaptic Connections Reveal High and Random Local Connectivity between CA3 Pyramidal Cells — Layous R, et al., Journal of Neuroscience 2025
- Voltage imaging reveals circuit computations in the raphe underlying serotonin-mediated motor vigor learning — Kawashima T, et al., Neuron 2025