Archer2

Archaerhodopsin variant that further suppresses photocurrents at the expense of slower kinetics and lower sensitivity than its Archer1.

Category: Opsin GEVI · Published: 2014 · Nature Communications 2014

Dynamic Range: 60% ΔF/F per 100mV

Brightness: 3× vs arch

Research Papers (3)

Archaerhodopsin variants with enhanced voltage-sensitive fluorescence in mammalian and Caenorhabditis elegans neurons — Flytzanis NC, Bedbrook CN, Chiu H, Engqvist MKM, Xiao C, Chan KY, Sternberg PW, Arnold FH, Gradinaru V, Nature Communications 2014
Rational Design of Far-Red Archaerhodopsin-3-Based Fluorescent Genetically Encoded Voltage Indicators: from Elucidation of the Fluorescence Mechanism in Archers to Novel Red-Shifted Variants — Nikolaev DM, et al., ACS Physical Chemistry Au 2024
Semirational Protein Engineering Yields Archaerhodopsin-3-Based Fluorescent Genetically Encoded Voltage Indicators with Enhanced Brightness and Red Shifted Absorption Bands — Nikolaev DM, et al., Chem & Bio Engineering 2025