ASAP4b
Bright-optimized ASAP4 variant with superior brightness and photostability for extended two-photon recordings.
Category: VSD-cpGFP GEVI · Published: 2023 · Nature Methods 2023
Speed: τ_on=17.66 ms, τ_off=22.85 ms
Dynamic Range: 180% ΔF/F per 100mV
Sensitivity: 35% ΔF/F per AP
Brightness: 0.4468× vs asap3
Research Papers (5)
- A positively tuned voltage indicator for extended electrical recordings in the brain — Evans SW, Shi DQ, Chavarha M, et al., Nature Methods 2023
- Improving positively tuned voltage indicators for faster kinetics and higher contrast — Lee S, Zhang G, Hao YA, et al., bioRxiv 2024
- Positive-going hybrid indicators for voltage imaging in excitable cells and tissues — Liu S, et al., Science Advances 2025
- Voltage imaging reveals hippocampal inhibitory dynamics shaping pyramidal memory-encoding sequences — Taxidis J, et al., Nature Neuroscience 2025
- Imaging sensory transmission and neuronal plasticity in primary sensory neurons with a positively tuned voltage indicator — Zhang Y, et al., Nature Communications 2025