ASAP4e

Speed-optimized ASAP4 variant with fast kinetics and a large fluorescence increase per action potential.

Category: VSD-cpGFP GEVI · Published: 2023 · Nature Methods 2023

Speed: τ_on=2.62 ms, τ_off=5.69 ms

Dynamic Range: 210% ΔF/F per 100mV

Sensitivity: 23% ΔF/F per AP

Brightness: 0.362× vs asap3

Research Papers (3)

Voltage imaging reveals hippocampal inhibitory dynamics shaping pyramidal memory-encoding sequences — Taxidis J, et al., Nature Neuroscience 2025
Imaging sensory transmission and neuronal plasticity in primary sensory neurons with a positively tuned voltage indicator — Zhang Y, et al., Nature Communications 2025
Retroreflective beam multiplexing enables high-throughput two-photon voltage imaging in vivo — Liu Z, Han M, Chen Y, Downs NP, Wu J, bioRxiv 2025