ASAP5
Optimized for detecting subthreshold activity, with the steepest F-V slope near resting potential.
Category: VSD-cpGFP GEVI · Published: 2024 · Neuron 2024
Speed: τ_on=2.97 ms, τ_off=2.62 ms
Dynamic Range: -57% ΔF/F per 100mV
Sensitivity: 34% ΔF/F per AP
Brightness: 1× vs asap3
Research Papers (8)
- A fast and responsive voltage indicator with enhanced sensitivity for unitary synaptic events — Hao YA, Lee S, Roth RH, Natale S, Gomez L, Taxidis J, et al., Neuron 2024
- Ultrasensitive voltage imaging reveals distinct electrical microdomains in neurons — Hao YA, Jayne LL, Lee S, Dittrich MN, Zhang M, et al., bioRxiv 2026
- Deep two-photon voltage imaging with adaptive excitation — Zhao S, Hebert E, Gruzdeva A, Mahishi D, Takahashi H, Lee S, Hao YA, Lin MZ, Yapici N, Xu C, Research Square 2024
- A deep learning framework for automated and generalized synaptic event analysis — O'Neill PS, Baccino-Calace M, Rupprecht P, Lee S, Hao YA, Lin MZ, Friedrich RW, Mueller M, Delvendahl I, eLife 2025
- Selective life-long suppression of an odor processing channel in response to critical period experience — Leier HC, et al., bioRxiv 2025
- Retroreflective beam multiplexing enables high-throughput two-photon voltage imaging in vivo — Liu Z, Han M, Chen Y, Downs NP, Wu J, bioRxiv 2025
- Kilohertz-rate two-photon voltage imaging of population dynamics in vivo — Zhang M, et al., bioRxiv 2026
- Designer indicators for two-photon recording of subthreshold voltage dynamics — Land MA, Galdamez M, Villette V, Zhu J, Lu X, Marosi M, et al., Nature Methods 2026