ASAP6c

Contrast-optimized sibling of ASAP6b with the largest per-spike fluorescence increase and signal-to-noise of the ASAP lineage for one- and two-photon spike detection in vivo.

Category: VSD-cpGFP GEVI · Published: 2026 · bioRxiv 2026

Speed: τ_on=3.93 ms, τ_off=4.41 ms

Dynamic Range: 222% ΔF/F per 100mV

Sensitivity: 70% ΔF/F per AP

Brightness: 1× vs asap4e

Research Papers (1)

Improving positively tuned voltage indicators for faster kinetics and higher contrast — Lee S, Zhang G, Hao YA, Roth RH, Sun Y, Dong C, Zhu J, Gomez LC, Natan RG, Jiang D, Liu LX, Testa-Silva G, Hiramoto A, Roska B, Feldman D, Ji N, Clandinin TR, Giocomo L, Ding J, Lin MZ, bioRxiv 2026