Bongwoori
ArcLight-derived voltage indicator with an improved voltage-sensing domain.
Category: VSD-single FP · Published: 2015 · Journal of Neuroscience 2015
Speed: τ_on=8 ms, τ_off=7 ms
Dynamic Range: -10% ΔF/F per 100mV
Sensitivity: 3.7% ΔF/F per AP
Brightness: 0.29× vs arclight
Research Papers (9)
- Combinatorial mutagenesis of the voltage-sensing domain enables the optical resolution of action potentials firing at 60 Hz by a genetically encoded fluorescent sensor of membrane potential — Piao HH, et al., Journal of Neuroscience 2015
- Improving a genetically encoded voltage indicator by modifying the cytoplasmic charge composition — Lee S, et al., Scientific Reports 2017
- Optical consequences of a genetically-encoded voltage indicator with a pH sensitive fluorescent protein — Kang BE, et al., Neuroscience Research 2019
- Engineering photoactivatability in genetically encoded voltage and pH indicators — Lee S, et al., Frontiers in Cellular Neuroscience 2019
- In vitro testing of voltage indicators: Archon1, ArcLightD, ASAP1, ASAP2s, ASAP3b, Bongwoori-Pos6, BeRST1, FlicR1, and Chi-VSFP-Butterfly — Milosevic MM, et al., eNeuro 2020
- Mechanism of ArcLight derived GEVIs involves electrostatic interactions that can affect proton wires — Kang BE, et al., Biophysical Journal 2021
- Visualizing oscillations in brain slices with genetically encoded voltage indicators — Rhee JK, et al., Frontiers in Neuroanatomy 2021
- A trafficking motif alters GEVI activity implicating persistent protein interactions at the membrane — Lee S, et al., Biophysical Reports 2022
- Imaging electrical activity of retinal ganglion cells with fluorescent voltage and calcium indicator proteins in retinal degenerative rd1 blind mice — Jung Y, et al., ACS Chemical Neuroscience 2025