Cepheid1b

Red eFRET voltage indicator built by inserting the bright RFP donor mScarlet-I1.4 into the first extracellular loop of Ace(D81C) rhodopsin; the brighter (but less photostable) member of the Cepheid1 pair.

Category: eFRET GEVI · Published: 2023 · Science Advances 2023

Speed: τ_on=2.71 ms, τ_off=4.99 ms

Dynamic Range: -31% ΔF/F per 100mV

Sensitivity: 12.1% ΔF/F per AP

Brightness: 1.65× vs varnam

Research Papers (2)

Bright and sensitive red voltage indicators for imaging action potentials in brain slices and pancreatic islets — Han Y, Yang J, Li Y, Chen Y, Ren H, Ding R, Qian W, Ren K, Xie B, Deng M, Xiao Y, Chu J, Zou P, Science Advances 2023
Solaris: a panel of bright and sensitive hybrid voltage indicators for imaging membrane potential in cultured neurons — Yang J, Zhu S, Yang L, Peng L, Han Y, Hayward RF, Park P, Hu D, Cohen AE, Zou P, bioRxiv 2024