VARNAM
Voltage indicator using opsin-FRET architecture with red fluorescent protein for improved tissue penetration.
Category: eFRET GEVI · Published: 2018 · Nature Methods 2018
Speed: τ_on=0.88 ms, τ_off=0.8 ms
Dynamic Range: -10.8% ΔF/F per 100mV
Sensitivity: 4.8% ΔF/F per AP
Brightness: 2286× vs arch
Research Papers (7)
- Fast, in vivo voltage imaging using a red fluorescent indicator — Kannan M, Vasan G, Huang C, Haziza S, Li JZ, Inan H, Schnitzer MJ, Pieribone VA, Nature Methods 2018
- A high-speed, bright, red fluorescent voltage sensor to detect neural activity — Beck C, Gong Y, Scientific Reports 2019
- Screening and Cellular Characterization of Genetically Encoded Voltage Indicators Based on Near-Infrared Fluorescent Proteins — Monakhov MV, Matlashov ME, Colavita M, Song C, Shcherbakova DM, Antic SD, Verkhusha VV, Knopfel T, ACS Chemical Neuroscience 2020
- A far-red hybrid voltage indicator enabled by bioorthogonal engineering of rhodopsin on live neurons — Liu S, Lin C, Xu Y, Luo H, Peng L, Zeng X, Zheng H, Chen PR, Zou P, Nature Chemistry 2021
- Dual-polarity voltage imaging of the concurrent dynamics of multiple neuron types — Kannan M, Vasan G, Haziza S, Huang C, Chrapkiewicz R, Luo J, Cardin JA, Schnitzer MJ, Pieribone VA, Science 2022
- Sensitivity optimization of a rhodopsin-based fluorescent voltage indicator — Abdelfattah AS, et al., Neuron 2023
- Bright and sensitive red voltage indicators for imaging action potentials in brain slices and pancreatic islets — Han Y, Yang J, Li Y, Chen Y, Ren H, Ding R, Qian W, Ren K, Xie B, Deng M, Xiao Y, Chu J, Zou P, Science Advances 2023