QuasAr6a

Archon1 variant evolved through video-based pooled screening with improved SNR.

Category: Opsin GEVI · Published: 2023 · Nature Methods 2023

Speed: τ_on=1.8 ms, τ_off=1.3 ms

Dynamic Range: 73% ΔF/F per 100mV

Sensitivity: 26% ΔF/F per AP

Brightness: 1.7× vs archon1

Research Papers (4)

Video-based pooled screening yields improved far-red genetically encoded voltage indicators — Tian H, Davis HC, Wong-Campos JD, Park P, Fan LZ, Gmeiner B, Begum S, Werley CA, Borja GB, Upadhyay H, Shah H, Jacques J, Qi Y, Parot V, Deisseroth K, Cohen AE, Nature Methods 2023
Diminishing neuronal acidification by channelrhodopsins with low proton conduction — Hayward RF, Brooks FP 3rd, Yang S, Gao S, Cohen AE, eLife 2023
Retrograde endocannabinoid signaling at inhibitory synapses in vivo — Dudok B, Fan LZ, Farrell JS, Malhotra S, Homidan J, Kim DK, Wenardy C, Ramakrishnan C, Li Y, Deisseroth K, Soltesz I, Science 2024
Plasmonic Enhancement of Protein Function — Locarno M, Dong Q, Meng X, Glessi C, Hettema NM, Brandsma N, Blokhuizen S, Castaneda Garcia A, Ganapathy S, Post M, Schmidt T, van Roemburg L, Xu B, Cho CT, Laan L, Chien M, Brinks D, bioRxiv 2024