rEstus
Variant of ASAP3 optimized for non-excitable cells, shifting voltage sensitivity to match their characteristically negative resting potentials.
Category: VSD-cpGFP GEVI · Published: 2024 · Advanced Science 2024
Speed: τ_on=2 ms, τ_off=20 ms
Dynamic Range: -66% ΔF/F per 100mV
Brightness: 0.775× vs EGFP
Research Papers (4)
- An Ultrasensitive Genetically Encoded Voltage Indicator Uncovers the Electrical Activity of Non-Excitable Cells — Rühl P, et al., Advanced Science 2024
- Absolute Membrane Potential Recording with ASAP-Type Genetically Encoded Voltage Indicators Using Fluorescence Lifetime Imaging — Nair AG, et al., ACS Chemical Neuroscience 2025
- Crosstalk of KCNH1 and KCNH5 gain-of-function mutations leading to epilepsy and neurodevelopmental disorders — Bernert A, et al., Molecular Brain 2026
- Generation and characterization of a human induced pluripotent stem cell line (hiPSC) expressing the rEstus voltage sensor under doxycycline induction — Malan D, et al., Stem Cell Research 2026