SomArchon
Soma-targeted Archon1 variant designed for population voltage imaging.
Category: Opsin GEVI · Published: 2019 · Nature 2019
Speed: τ_on=0.6 ms, τ_off=1.1 ms
Dynamic Range: 30% ΔF/F per 100mV
Sensitivity: 45% ΔF/F per AP
Brightness: 28× vs arch
Research Papers (16)
- Population imaging of neural activity in awake behaving mice — Piatkevich KD, Bensussen S, Tseng HA, Shroff SN, Lopez-Huerta VG, Park D, Jung EE, Shemesh OA, Straub C, Gritton HJ, Romano MF, Costa E, Sabatini BL, Fu Z, Boyden ES, Han X, Nature 2019
- All-optical electrophysiology reveals the role of lateral inhibition in sensory processing in cortical layer 1 — Fan LZ, Kheifets S, Bohm UL, Wu H, Piatkevich KD, Xie ME, Parot V, Ha Y, Evans KE, Boyden ES, Takesian AE, Cohen AE, Cell 2020
- Craniotomy Procedure for Visualizing Neuronal Activities in Hippocampus of Behaving Mice — Wang Y, Zhu D, Liu B, Piatkevich KD, Journal of Visualized Experiments 2021
- Large-scale voltage imaging in behaving mice using targeted illumination — Xiao S, Lowet E, Gritton HJ, Fabris P, Wang Y, Sherman J, Mount R, Tseng HA, Man HY, Mertz J, Han X, iScience 2021
- Region-specific effects of ultrasound on individual neurons in the awake mammalian brain — Tseng HA, Mahoney CE, Bhatt DK, Xiao S, Bhatt RA, De La Croix Bhatt RS, Han X, iScience 2021
- Visualizing Oscillations in Brain Slices With Genetically Encoded Voltage Indicators — Rhee JK, Iwamoto Y, Baker BJ, Frontiers in Neuroanatomy 2021
- Deep brain stimulation creates informational lesion through membrane depolarization in mouse hippocampus — Lowet E, Kondabolu K, Zhou S, Mount RA, Ravasio C, Han X, Nature Communications 2022
- Membrane Voltage Dynamics of Parvalbumin Interneurons Orchestrate Hippocampal Theta Rhythmicity — Tseng HA, Bhatt DK, Bhatt RS, Han X, bioRxiv 2022
- Theta and gamma rhythmic coding through two spike output modes in the hippocampus during spatial navigation — Lowet E, Sheehan DJ, Chialva U, De Oliveira Pena R, Mount RA, Xiao S, Zhou SL, Tseng HA, Gritton H, Shroff S, Kondabolu K, Cheung C, Wang Y, Piatkevich KD, Boyden ES, Mertz J, Hasselmo ME, Rotstein HG, Han X, Cell Reports 2023
- Striatal cholinergic interneuron membrane voltage tracks locomotor rhythms in mice — Shroff SN, Lowet E, Sridhar S, Gritton HJ, Abumuaileq M, Tseng HA, Cheung C, Zhou SL, Kondabolu K, Han X, Nature Communications 2023
- Photothrombosis induced cortical stroke produces electrographic epileptic biomarkers in mice — Shaw DC, Kondabolu K, Bhatt DK, Han X, bioRxiv 2024
- Slow and fast cortical cholinergic arousal is reduced in a mouse model of focal seizures with impaired consciousness — Sieu LA, Bhatt DK, Bhatt RS, Han X, Cell Reports 2024
- Large-scale deep tissue voltage imaging with targeted-illumination confocal microscopy — Xiao S, Cunningham WJ, Kondabolu K, Lowet E, Moya MV, Mount R, Ravasio C, Bortz E, Shaw D, Economo MN, Han X, Mertz J, Nature Methods 2024
- Relative phase of membrane potential theta oscillations between individual hippocampal neurons code space — Athif M, et al., bioRxiv 2025
- Imaging high-frequency voltage dynamics in multiple neuron classes of behaving mammals — Haziza S, et al., Cell 2025
- Transcranial ultrasound stimulation modulates neuronal membrane potentials across broad timescales in the awake mammalian brain — Bortz E, et al., Brain Stimulation 2025