VADER1

Red-emitting voltage indicator built on the JEDI/ASAP architecture with a circularly permuted mApple, evolved for reliable spike detection under two-photon excitation in vivo.

Category: VSD-single FP · Published: 2026 · bioRxiv 2026

Speed: τ_on=1.41 ms, τ_off=0.79 ms

Dynamic Range: 192% ΔF/F per 100mV

Sensitivity: 40% ΔF/F per AP

Brightness: 0.85× vs flicr2

Research Papers (1)

A red-emitting, genetically encoded indicator for two-photon voltage recording in vivo — Yang S, McDonald AJ, Lu X, Villette V, Hakam N, Galdamez M, et al., bioRxiv 2026