VARNAM2

Second-generation red-shifted eFRET voltage indicator derived from VARNAM with improved voltage sensitivity for low-power in vivo imaging in behaving animals.

Category: eFRET GEVI · Published: 2022 · Science 2022

Speed: τ_on=0.95 ms, τ_off=1.21 ms

Dynamic Range: -19.1% ΔF/F per 100mV

Sensitivity: 7.3% ΔF/F per AP

Brightness: 1× vs varnam

Research Papers (3)

Dual-polarity voltage imaging of the concurrent dynamics of multiple neuron types — Kannan M, Vasan G, Haziza S, Huang C, Chrapkiewicz R, Luo J, Cardin JA, Schnitzer MJ, Pieribone VA, Science 2022
Imaging high-frequency voltage dynamics in multiple neuron classes of behaving mammals — Haziza S, Chrapkiewicz R, Zhang Y, Kruzhilin V, Li J, Delamare G, Swanson R, Buzsáki G, Kannan M, Vasan G, Lin MZ, Zeng H, Daigle T, Schnitzer MJ, Cell 2025
Prefrontal gamma oscillations engage dynamic cell type-specific configurations to support flexible behavior — Phensy AJ, Hagopian LL, Costello CM, Haziza S, Ghenand O, Zhang Y, Schnitzer MJ, Sohal V, bioRxiv 2025